In Cytokines and the CNS,
leading practicing doctors and scientists review the current status of
cytokines, with an emphasis on their role in developmental and
pathological processes in the central nervous system (CNS). They describe
various cytokine families and their receptors, focusing on the delineation
of known mechanisms by which ligand-receptor interactions mediate
biological effects. The book also emphasizes interactions between
cytokines and other biological regulators at the cellular and molecular
level, and considers in detail tissue-specific effects exerted on CNS
cells by cytokines. Cytokine regulation of CNS development also is
discussed.
With this background, Cytokines and the CNS then
explores how cytokine action may be implicated in various human disease
processes, including inflammation, neoplasia, degeneration, and the
neurological manifestations of HIV infection.
This book features cutting-edge information in this
rapidly expanding area of investigation - the result of explosive growth
in the understanding of cytokines' role in hematopoiesis, inflammation,
and immunity, combined with tremendous advances in the identification and
characterization of neurotrophic factors. Cytokines and the CNS is
well organized and comprehensive, contains chapters by practicing
researchers from the fields of neurobiology and immunology/hematopoiesis,
and presents both practical and conceptual information.
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